FDA Reviews Marijuana-min

The year has just begun and there is already big news in the Cannabis world. On January 12th, 2024, Texan lawyer, Matthew Zorn, released a letter from the HHS to the DEA regarding their suggestion to reclassify marijuana from a Schedule I drug to a Schedule III drug. This means that Marijuana is potentially being moved from a category with heroin to a category with testosterone. This letter provides much insight into what is known about marijuana and its potential as a drug. 

 

Marijuana’s Reclassification

Marijuana is currently classified as a Schedule 1 Drug, putting it in the same category as heroin and LSD. For clarification, when the term “marijuana” is used throughout this article, it refers to all parts of the cannabis sativa plant. In recent months, Scientists from the U.S. Food and Drug Administration have stated in recently released documents that marijuana “has a potential for abuse less than the drugs or other substances in Schedules I and II” and should be reclassified as a Schedule III. This document also reveals evidence backing it as a medical treatment.

According to the Alcohol Policy Information System, Marijuana has been a Schedule I Drug since the Controlled Substances Act of 1970. In the years after that legislation, 11 states moved to decriminalize cannabis possession. As many following the Cannabis Rights movement know, the cause has only recently begun to move. 

This possible reschedule started in 2022. That year, President Joe Biden asked US Health and Human Services Secretary Xavier Becerra and the attorney general to start reviewing the current scheduling of marijuana under federal law.

In August of 2023, HHS Assistant Secretary for Health Adm. Rachel Levine wrote a 252-page letter to the Drug Enforcement Administration. In this letter, she states her support for the reclassification to Schedule III. 

The Schedule III category is for “drugs with a moderate to low potential for physical and psychological dependence”. This category includes ketamine, testosterone, and Tylenol with codeine. A doctor can prescribe all these substances.

The HHS originally released this letter, but heavily redacted much of the information. Upon its release, a Texan lawyer, Matthew Zorn, filed for a Freedom of Information Act (FOIA). After months of deliberation, on January 11th, The DEA agreed to release the document in its entirety. 

 

How and Why Can Marijuana Be Reclassed?

When determining if a drug can be reclassified, one must consider 8 factors. Those factors are potential for abuse, medicinal value, state of scientific knowledge, its history, the significance of abuse, the risk to public health, physiologic dependency, and if it’s derived from a controlled substance. 

Under these factors, it was found that marijuana abuse may lead to moderate or low physical dependence or high psychological dependency. Furthermore, they discuss how marijuana withdrawal is short, compared to other substances. On page 60 of Levine’s letter, it states “…In heavy, chronic individuals who use marijuana, drug discontinuation can lead to a withdrawal syndrome(Budney & Hughes, 2006; Haney et al., 1999). Most marijuana withdrawal symptoms begin within 24-48 hours of drug discontinuation, peak within 2-6 days, and reduce over 1-2 weeks as∆9-THC levels decline(Connor et al., 2021).” In comparison, heroin withdrawal has an onset of 8-24 hours after the last use and can peak between 3-10 days, as stated by American Addiction Centers.

In this document, they do highlight evidence of marijuana having medicinal value but they preface this data with the following statement. “The analysis of, and conclusions regarding, the available data are not meant to imply that safety and effectiveness have been established for marijuana that would support FDA approval of marijuana for a particular indication.” 

Overall, they found that marijuana fits the criteria to be reclassified from Schedule I to Schedule III, due to its lower potential for abuse, low dependency, and potential medicinal value.

What is Drug Scheduling?

As mentioned before, The Controlled Substance Act of 1970 created the Scheduling system for drugs and substances. Currently, there are 5 categories. Below is a brief synopsis of each category and the substances they include:

Schedule Description Examples
Schedule I Schedule I drugs are substances with no accepted medical use and high potential for abuse. – Heroin

– LSD

– Ecstasy

Schedule II Schedule II drugs are substances that have a high potential for abuse and lead to severe psychological and physical dependency. -Cocaine

-Methamphetamine

-Morphine

Schedule III Schedule III drugs are substances with moderate to low potential for physical and psychological dependency. -Tylenol with Codeine

– Anabolic steroids

– Ketamine

Schedule IV Schedule IV drugs are substances with a low potential for abuse and a low risk of dependency. – Xanax

– Valium

– Lorazepam

Schedule V Schedule V drugs are substances with a lower potential for abuse than Schedule IV and consist of primarily prescriptions containing limited quantities of certain narcotics – Robitussin AC

– Epidiolex (cannabidiol)

– Anticonvulsants

What does this mean for the Marijuana Industry?

While this doesn’t mean we are anywhere close to marijuana legalization across all states, this letter shows a step in a positive direction. This reclassification would allow further research, potentially increasing the availability of marijuana-based pharmaceuticals and an open mind towards its regulation at state and federal levels.

While this reclassification may not do much in the way of regulation or legalization, it provides much insight into what is known about marijuana and its potential as a medicinal treatment. Thanks to Matthew Zorn, this information is now shared with the public and can be read in its entirety. This letter inspires hope for the future of marijuana and a brighter tomorrow. Stay tuned to hear more updates about any legislation or decisions made about cannabis.

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